In order to enhance the surgical safety of patients using antithrombotic drugs, the hospital has formed a cross-departmental project team, including surgeons, pharmacists, operating room members, health information technicians and quality center specialists, to develop our preoperative antithrombotic drug discontinuation/resumption decision-making system. The system also uses cloud-based medication data to assist surgeons in correctly deciding whether the patient need to discontinued taken antithrombotic drugs or not. In addition, the intelligent decision-making system automatically preliminarily evaluates the bleeding risk and embolism risk according to the surgical method and the patient's past history, and the system automatically recommends the start date of discontinuation of antithrombotic drugs. Physicians can still adjust the drug withdrawal time according to the type of surgery and the patient's condition. After surgery, the computerized physician order entry system will remind the physician to resume the prescription of anti-thrombotic drugs for patients who had discontinued before the surgery. The pharmacist will tracking the patients if the medication resumed as expected to avoid events of thromboembolism due to discontinuation too long, which will affect the patient's future life. It is our scope that by introducing the intelligent decision-making system, the safety of patients' surgery and medication can be improved.