Dr. Pongsatorn Supaattagorn
Director of Ubon Ratchathani Cancer Hospital, Thailand
Dr. Pongsatorn Supaattagorn
Director of Ubon Ratchathani Cancer Hospital, Thailand
Speaker's Biography
Dr. Pongsatorn is the Director of Ubonratchathani Cancer Hospital, Thailand. He received his medical degree from Khonkaen University and completed his radiation oncology fellowship training at King Chulalongkorn Memorial Hospital, Thailand. Dr. Pongsatorn has been a professional attending physician of radiation oncology since 1997. He is also the consultant of the tumor registry unit.
As an oncologist, Dr. Pongsatorn is interested in cancer genetics study, especially genetic counseling. So, he and his team initiated a counseling clinic in 2020 focusing on common cancers such as hereditary breast-ovarian and colorectal cancer. He is constantly improving the service. His team has also worked with many institutes to research cancer genetics.
Topic
Precision Medicine Implement in Oncology: Cancer
Genetic Risk Assessment and Counseling
Abstract
Hereditary cancer syndrome is a type of inherited disorder with a higher than average risk of certain types of cancer. It causes 10% of cancer cases, and an estimated 20% of cancer patients have a positive family history of cancer. This type of cancer is caused by germline mutation. It is heritable. Genetic counseling is crucial for approaching this type of cancer.
Two common hereditary cancers (Hereditary Breast and Ovarian Cancer syndrome (HBOC) and Lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer) will be presented, including risk factors, genetic testing, and mutation carrier management.
Breast cancer susceptibility gene 1 (BRCA1) and gene 2 (BRCA2) mutations are associated with about 20% of hereditary breast and ovarian cancers (HBOC). Breast and ovarian cancer risk is up to 60 % in women with mutations in either BRCA1 or BRCA2. Approaches to the care of patients with HBOC are risk-reducing surgery, including Bilateral mastectomy, bilateral oophorectomy, or Surveillance.
Lynch syndrome is the most common cause of inherited colorectal cancer (CRC). The risk of cancer in these patients is up to 80 %. The most common Lynch syndrome-related cancer is colorectal, endometrium, and ovarian cancer. For Lynch syndrome, Surveillance with a colonoscopy every 2-5 years is recommended.